The Free State of Thuringia and the Hauts-de-France Region together with the European University Alliances (EUA) SUNRISE and BAUHAUS4EU will dedicate an interactive workshop to the collaboration of EUAs with regional ecosystems. They believe that the European network of our EUA has great value for territorial development and for solving regional challenges linked to innovation, demographic change and industrial and societal transition. Inspired by the 'Quadruple Helix' model, they invite participants to share their experience, discuss and shape future collaboration models and contribute to building stronger connections between these interregional networks of universities and their regions.