Designing new methods and tools for production of an alterna

Call title:
Safe by design, from science to regulation: metrics and main sectors
Types of partners sought
√ Industrial partners in the chemical processing industry √ Academic partners (in the field of chemistry, and chemical and process engineering)

This project aims at designing and developing new methods of production a new raw material to replace nickel compounds deregulated due to health and safety and environmental consequences of its use, thus reducing the environmental, health and safety risks and increasing the performance throughout the whole life cycle. Moreover, the project will develip risk assessment and post-use monitoring tools.This project envisages working with businesses in the chemical processing industry to research and design production methods of materials to develop safer products.

Specific Challenge: Risk management involves quantifying hazard (toxicity) and exposure, and taking the necessary steps to reduce both to acceptable levels, ideally at an early stage of the nanomaterial development process (Safe-by-Design). Various industrial sectors, and in particular structural or functional materials, coatings and cosmetics, as well as pharma and health technology are currently searching for ways to mitigate possible risks from nanomaterials and nano-containing products. The challenge now is to distil existing methods into simple, robust, cost-effective methods for monitoring and modelling of physical-chemical properties and biological effect assessment of nanomaterials in relevant use conditions including in product-relevant matrices.


  • Degradation of nano-enabled products and ageing of nanomaterials, and mixture toxicity;
  • New Safe by Design methods that enable reduction of hazard and exposure through design to an acceptable risk level without affecting the material performance and guide development of safer products at different stages;
  • Implementation of control measures and mitigation strategies for nanomaterials specific scenarios in various industrial sectors to reach acceptable regulatory risk level on the effectiveness of such measures, and develop computational approaches to model them;
  • For this topic the parallel calls scheme is envisaged with the USA-NNI. Resulting projects should establish close cooperation mechanisms. Legal, policy making and Responsible Research and Innovation aspects should be integrated in the proposal.

Activities should start at TRL 4 and achieve TRL 6 at the end of the project.

Expected Impact:

  • Safe by design approaches and tools at an early stage of the nanomaterial development process;
  • Quality workplaces that ensure maximum technical and economic performance in line with acceptable risk levels;
  • Control and mitigate exposure to acceptable risk level in case after release of nanomaterials from products;

Develop and validate low-cost techniques for delivering an integrated exposure driven risk assessment and the associated design of the required post-use monitoring.

Working group:
Advanced Manufacturing & NanotechnologyEnergy & Climate Change
Deadline of the call: